Isabella I of Castile

Pope Sixtus IV authorized the Tribunal of the Holy Office of the Inquisition in 1478, providing the legal basis for its creation.

The definitive peace agreement was signed in Alcáçovas, ending the War of the Castilian Succession and defining Atlantic spheres of influence.

Monarchs ordered Jews in Seville, Cordoba, and Cadiz dioceses to relocate to Extremadura within six months.

Castilian forces initiated an eight-month siege of Granada in April 1491, marking the final phase of the Granada War.

A provisional surrender was signed on 25 November 1491, granting the city two months to finalize terms with Castilian forces.

Muhammad XI surrendered the Emirate, city, and Alhambra to Castilian forces on 2 January 1492.

The Catholic Monarchs issued the decree expelling unconverted Jews on 31 March 1492.

Nebrija published the first grammar of a modern European language in 1492, dedicated to Queen Isabella I of Castile.

The grammar was presented to Isabella of Castile in Salamanca, where she questioned its merit and Bishop Talavera responded on Nebrija's behalf.

Pope Alexander VI issued Inter caetera on 4 May 1493, granting Spain rights to lands west and south of a line 100 leagues from the Azores or Cape Verde.

Joanna entered a proxy marriage at the Palacio de los Vivero in Valladolid, a site historically significant as the location of her parents' secret union.

Joanna traveled from the port of Laredo to Brabant in the Low Countries to join Philip for the formal wedding ceremony.

Isabella granted citizenship and legal freedom to non-rebellious natives in the colonies.

Isabella instructed descendants to treat indigenous Americans fairly and remedy wrongs.