Episode 2 of 3

1878 Mississippi Valley Outbreak

When
1878 (started by March)
Where
Lower Mississippi Valley
Part of
Yellow fever epidemic in the Mississippi Valley

A severe yellow fever epidemic swept through the lower Mississippi Valley in 1878; Memphis recorded more than 5,000 deaths in its official register.

The outbreak had started by March 1878 and was thought to be connected to an ongoing yellow fever outbreak in Havana. It was the worst epidemic that occurred in the state of Mississippi. In Memphis, the epidemic's principal focus, more than 5,000 people were listed in the official register of deaths between July 26 and November 27, 1878; that register window reflects the Memphis death toll rather than the epidemic's overall end.

Sources

  1. Lower Mississippi Valley yellow fever epidemic of 1878 Wikipedia, revision of 2026-10-06
  2. Memphis, Tennessee Wikipedia, revision of 2026-09-26

Machine-drafted from the cited Wikipedia passages and checked by a reviewing model, not by a human editor. Every passage cites the revision it was written from; dates and places follow those passages.