Domínguez led the expedition out of Santa Fe on July 29, 1776, with Escalante, cartographer Miera y Pacheco, and ten men.

On July 29, 1776, Atanasio Domínguez led the expedition from Santa Fe with fellow friar Silvestre Vélez de Escalante and cartographer Bernardo de Miera y Pacheco. The purpose was to find a route across the largely unexplored continental interior from Santa Fe to Spanish missions in Las Californias, such as the presidio at Monterey. The party traveled with ten men, and the initial part of the journey followed the route taken by Juan Rivera eleven years earlier into the Ute country of southwestern Colorado.

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